Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL/6 mice subjected to the chronic mild stress model of depression.

@article{Kubera2001ProlongedDT,
  title={Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL/6 mice subjected to the chronic mild stress model of depression.},
  author={Marta Kubera and Michael Maes and Vladimir Holan and Agnieszka Basta-Kaim and Adam Roman and Jashovam Shani},
  journal={Journal of affective disorders},
  year={2001},
  volume={63 1-3},
  pages={171-8}
}
BACKGROUND Depression is associated with activation of the inflammatory response system (IRS). In humans, antidepressants significantly increase the production of interleukin-10 (IL-10), a negative immunoregulatory cytokine. The aims of the present study were to examine the effects of desipramine, a tricyclic antidepressant, on the IRS in C57BL/6 mice with and without exposure to chronic mild stress (CMS). METHODS We examined the effects of desipramine on the cytotoxic activity of natural… CONTINUE READING