Prolonged delivery of apomorphine through the buccal mucosa, towards a noninvasive sustained administration method in Parkinson's disease: in vivo investigations in pigs.

@article{Itin2020ProlongedDO,
  title={Prolonged delivery of apomorphine through the buccal mucosa, towards a noninvasive sustained administration method in Parkinson's disease: in vivo investigations in pigs.},
  author={Constantin Itin and Rinat Komargodski and Dinorah Barasch and Abraham J. Domb and Amnon Hoffman},
  journal={Journal of pharmaceutical sciences},
  year={2020}
}
In the current work, prolonged systemic delivery of apomorphine via buccal mucosa was shown to be a promising treatment for Parkinson`s disease as a substitute for clinically utilized subcutaneous infusions. Due to extensive 'first-pass' metabolism, apomorphine is administered parenterally to bypass liver metabolism. Drawbacks of parenteral administration cause low patient compliance and adherence to treatment. On the other hand, while also bypassing the liver, delivery through buccal mucosa… 
View on PubMed
doi.org

References

SHOWING 1-10 OF 63 REFERENCES
Controlled delivery of apomorphine through buccal mucosa, towards a noninvasive administration method in Parkinson's disease: a preclinical mechanistic study.
TLDR
The novel concept of APO prolonged release buccal administration as a noninvasive substitute for parenteral infusions in treating Parkinson's disease is verified.
In Vivo Buccal Delivery of the Peptide Drug Buserelin with Glycodeoxycholate as an Absorption Enhancer in Pigs
TLDR
The results of this study demonstrate that buccal administration with the use of absorption enhancers is a useful approach for the delivery of peptide drugs such as buserelin.
Prolonged oral transmucosal delivery of highly lipophilic drug cannabidiol.
TLDR
The absorption profile indicates that cannabidiol, as well as other lipophilic molecules, should be delivered through oral mucosa for systemic absorption from a device that conceals the drug and prevents its washout by the saliva flow and subsequent ingestion into gastrointestinal tract.
Pharmacokinetic-Pharmacodynamic Relationships of Apomorphine in Patients with Parkinson’s Disease
TLDR
The population pharmacokinetic-pharmacodynamic data reflect the clinical observations of steep dose-effect curves if apomorphine is used in patients with random ‘on-off’ fluctuations and could be helpful in predicting the clinical effects of apomorphicine in the several subgroups of patients with Parkinson’s disease.
Stepwise Intravenous Infusion of Apomorphine to Determine the Therapeutic Window in Patients with Parkinson's Disease
TLDR
The stepwise increase and decrease of the intravenous infusion rate is a suitable tool for the establishment of the concentration-effect relation of apomorphine in individual patients, and the finding of a narrow therapeutic window, in which the onset concentrations vary from patient to patient, underlines the need for accurate and individualized dosing.
Creating systemic oral transmucosal drug delivery strategies: Case study of APL-130277
TLDR
A case study of Cynapsus Therapeutics' APL-130277, a sublingual apomorphine formulation in clinical development for Parkinson's disease exemplifies the scientific, clinical and commercial considerations for systemic oral transmucosal drug delivery.
Conscious and anaesthetised Göttingen mini-pigs as an in-vivo model for buccal absorption – pH-dependent absorption of metoprolol from bioadhesive tablets
TLDR
A pH-dependent absolute bioavailability of metoprolol when administrated as bioadhesive buccal tablets to anaesthetised mini-pigs was shown, and the anaesthesia was found to delay the time to reach maximal plasma concentration of metobrolol as compared to the conscious pig model when administrating as buccals.
Buccal tissues and cell culture.
TLDR
The development of a small, thin flexible device that causes minimal disruption to normal activities such as eating, drinking, and talking is the ultimate aim of this area of drug delivery research, and the degree of drug permeation through the buccal mucosa must be determined.
Critical evaluation of permeation enhancers for oral mucosal drug delivery
Background: Drug delivery via oral mucosa is an alternative method of systemic administration for various classes of therapeutic agents. Among the oral mucosae, buccal and sublingual mucosae are the…
Histological and bioadhesion studies on buccal bioadhesive tablets containing a penetration enhancer sodium glycodeoxycholate
Abstract For many drugs, buccal route offers many advantages over conventional routes of delivery with an improved bioavailability due to the avoidance of degradation in the gastrointestinal tract…
...
1
2
3
4
5
...