Prolonged delivery of apomorphine through the buccal mucosa, towards a noninvasive sustained administration method in Parkinson's disease: in vivo investigations in pigs.

@article{Itin2020ProlongedDO,
  title={Prolonged delivery of apomorphine through the buccal mucosa, towards a noninvasive sustained administration method in Parkinson's disease: in vivo investigations in pigs.},
  author={Constantin Itin and Rinat Komargodski and Dinorah Barasch and Abraham J. Domb and Amnon Hoffman},
  journal={Journal of pharmaceutical sciences},
  year={2020}
}
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A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson’s disease
TLDR
A deep eutectic-based ternary solvent system that self-emulsifies in situ following subcutaneous injection and entraps apomorphine allows a 48-h duration of detectable drug concentration in the plasma of pigs, allowing a remarkable improvement over the clinical comparator.

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