Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat.

@article{Strauss2000ProlongedCI,
  title={Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat.},
  author={Kenneth I. Strauss and Mary F. Barbe and Robert M. Marshall and Ramesh Raghupathi and Samar Mehta and Raj K. Narayan},
  journal={Journal of neurotrauma},
  year={2000},
  volume={17 8},
  pages={695-711}
}
Cyclooxygenase-2 (COX2) is a primary inflammatory mediator that converts arachidonic acid into precursors of vasoactive prostaglandins, producing reactive oxygen species in the process. Under normal conditions COX2 is not detectable, except at low abundance in the brain. This study demonstrates a distinctive pattern of COX2 increases in the brain over time following traumatic brain injury (TBI). Quantitative lysate ribonuclease protection assays indicate acute and sustained increases in COX2… CONTINUE READING

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