Prolonged cortical silent period but normal sensorimotor plasticity in spinocerebellar ataxia 6.

@article{Teo2008ProlongedCS,
  title={Prolonged cortical silent period but normal sensorimotor plasticity in spinocerebellar ataxia 6.},
  author={James T H Teo and S. A. Schneider and Binith Joseph Cheeran and Miguel Fern{\'a}ndez-Del-Olmo and Paola Giunti and John C. Rothwell and Kailash P Bhatia},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2008},
  volume={23 3},
  pages={378-85}
}
Spinocerebellar ataxia 6 (SCA6) is a hereditary disease characterized by a trinucleotide repeat expansion in the CACNA1A gene and late-onset bilateral cerebellar atrophy. It is unclear if there is significant pathology outside of the cerebellum. We used transcranial magnetic stimulation to assess sensorimotor cortical circuits and cortical plasticity in 8 SCA6 patients and 8 age-matched controls. Behavioral performance was assessed using a rhythmic tapping task. Neurophysiological measures of… CONTINUE READING