Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice.

@article{Schwaller1999ProlongedCC,
  title={Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice.},
  author={Beat Schwaller and Josh R. Dick and Gurtej K Dhoot and Stefanie Carroll and Gerta Vrb{\'o}va and Pierluigi Nicotera and D. A. Pette and Adrian Wyss and Horst Bluethmann and Willi H. Hunziker and Marco R Celio},
  journal={The American journal of physiology},
  year={1999},
  volume={276 2 Pt 1},
  pages={
          C395-403
        }
}
The calcium-binding protein parvalbumin (PV) occurs at high concentrations in fast-contracting vertebrate muscle fibers. Its putative role in facilitating the rapid relaxation of mammalian fast-twitch muscle fibers by acting as a temporary buffer for Ca2+ is still controversial. We generated knockout mice for PV (PV -/-) and compared the Ca2+ transients and the dynamics of contraction of their muscles with those from heterozygous (PV +/-) and wild-type (WT) mice. In the muscles of PV-deficient… CONTINUE READING

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