Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: a phase II study in patients with disseminated colorectal cancer.

@article{Leichman1993ProlongedCI,
  title={Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: a phase II study in patients with disseminated colorectal cancer.},
  author={Cynthia Gail Leichman and Lawrence Leichman and Colin Paul Spears and Peter. J. Rosen and Susan Jeffers and Susan Groshen},
  journal={Journal of the National Cancer Institute},
  year={1993},
  volume={85 1},
  pages={41-4}
}
BACKGROUND Biochemical modulation of bolus fluorouracil (5-FU) by addition of leucovorin to the treatment regimen has increased response in patients with disseminated colorectal cancer from fewer than 20% to more than 40%. In view of the short half-life of 5-FU and its cell cycle specificity, it may be that infusion rather than intravenous bolus injection would increase efficacy. Furthermore, the advent of safer indwelling intravenous catheters and pump technology, allowing home and ambulatory… CONTINUE READING
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