Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo.

@article{Hill2004ProlongedCT,
  title={Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo.},
  author={Matthew Nicholas Hill and David J. Froc and Christopher J. Fox and Boris B. Gorzalka and Brian R Christie},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 3},
  pages={859-63}
}
Adult male Long-Evans rats were administered the potent cannabinoid 1 receptor agonist HU-210 (100 microg/kg, i.p.) for 15 days continuously and their performance on a matching-to-place version of the Morris water maze was subsequently evaluated. Overall, experimental animals performed significantly worse initially on the reference memory component of this task, but their performance improved over 5 days until it was indistinguishable from that of control animals. Animals given HU-210 did not… CONTINUE READING

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