Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma.

@article{OByrne2009ProlongedBA,
  title={Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma.},
  author={Paul M O'Byrne and Just A. van der Linde and Donald W. Cockcroft and Gail M Gauvreau and John D. Brannan and Michael J. Fitzgerald and Richard M. Watson and Joanne Milot and Beth R. Davis and Megan Kersten O'Connor and Lorna Hart and Lawrence G. Korducki and Alan Lewis Hamilton and L. -P. Boulet},
  journal={The Journal of allergy and clinical immunology},
  year={2009},
  volume={124 6},
  pages={
          1217-21
        }
}
BACKGROUND Long-acting ss(2)-agonists are an established controller medication in asthma. BI 1744 is a novel L\long-acting ss(2)-agonist with a preclinical profile that suggests 24-hour bronchodilation and bronchoprotection may be achieved. OBJECTIVE To examine the bronchoprotective effects of single doses of BI 1744 against methacholine provocation in subjects with mild asthma. METHODS Thirty-one subjects with mild asthma were randomized to receive single doses of BI 1744 (2, 5, 10, 20… CONTINUE READING
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