Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection.

@article{Guillot2002ProlongedBO,
  title={Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection.},
  author={C{\'e}cile Guillot and Carole Guillonneau and Patrick Mathieu and Christian A. Gerdes and S{\'e}verine M{\'e}noret and C{\'e}cile Braudeau and Laurent Tesson and Karine Renaudin and Maria Graciela Castro and Pedro R. L{\"o}wenstein and Ignacio Anegon},
  journal={Journal of immunology},
  year={2002},
  volume={168 4},
  pages={1600-9}
}
Previous work on blockade of CD40-CD40 ligand interaction in mice and primates with anti-CD40 ligand mAbs has resulted in a moderate prolongation of allograft survival without the development of true allograft tolerance. In this study, we show in rats that adenovirus-mediated gene transfer of CD40Ig sequences into the graft resulted in prolonged (>200 days) expression of CD40Ig and in long-term (>300 days) survival. Recipients expressing CD40Ig displayed strongly (>90%) inhibited mixed… CONTINUE READING
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