Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes.

@article{GondrLewis2001ProlongedAP,
  title={Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes.},
  author={Timothy A. Gondr{\'e}-Lewis and Amy E. Moquin and James R. Drake},
  journal={Journal of immunology},
  year={2001},
  volume={166 11},
  pages={6657-64}
}
Although Ag-specific B lymphocytes can process Ag and express peptide-class II complexes as little as 1 h after Ag exposure, it requires 3-5 days for the immune system to develop a population of Ag-specific effector CD4 T lymphocytes to interact with these complexes. Presently, it is unclear how B cells maintain the expression of cell surface antigenic peptide-class II complexes until effector CD4 T lymphocytes become available. Therefore, we investigated B cell receptor (BCR)-mediated Ag… CONTINUE READING

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