Prolonged anti‐emetic activity and 5‐HT3‐receptor antagonism by BRL 46470 in conscious ferrets

  title={Prolonged anti‐emetic activity and 5‐HT3‐receptor antagonism by BRL 46470 in conscious ferrets},
  author={J. L. Bermudez and Gareth John Sanger},
  journal={Journal of Pharmacy and Pharmacology},
  • J. BermudezG. Sanger
  • Published 1 June 1994
  • Medicine, Chemistry, Biology
  • Journal of Pharmacy and Pharmacology
The anti-emetic activity of oral and intravenously-administered BRL 46470 (endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3yl)-2,3-dihydro-3,3- dimethyl-indole-1-carboxamide HCl) has been assessed in conscious ferrets. BRL 46470 (0.05-0.5 mg kg-1, p.o.) dose-dependently prevented emesis evoked over a 2 h period by total body X-irradiation. This anti-emetic activity occurred with oral or intravenously-administered BRL 46470 even when dosed 3-4 h before radiation. In conjunction with data obtained in… 
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