Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia.

@article{Orzyowska1999ProlongedAC,
  title={Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia.},
  author={O Orzyłowska and Barbara Oderfeld-Nowak and Małgorzata Zaremba and Sławomir Januszewski and Marek Mossakowski},
  journal={Neuroscience letters},
  year={1999},
  volume={263 1},
  pages={72-6}
}
We have investigated the pattern of expression of IL-1beta and IL-6 immunoreactivities in rat hippocampus after transient complete brain ischemia evoked by a 10 min cardiac arrest, at survival times ranging from 1 day to 28 days. To identify the cell types expressing the two immunoreactivities we used specific cell markers and combined staining procedures. In the intact brain IL-1beta and IL-6 were mainly localized in neurons particularly in pyramidal and granular cell layers. Ischemic insult… CONTINUE READING

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