Prolonged alteration of vasoconstrictor and vasodilator responses in rat knee joints by adjuvant monoarthritis.

@article{McDougall1995ProlongedAO,
  title={Prolonged alteration of vasoconstrictor and vasodilator responses in rat knee joints by adjuvant monoarthritis.},
  author={Jason J McDougall and Seyed Morteza Karimian and William Russell Ferrell},
  journal={Experimental physiology},
  year={1995},
  volume={80 3},
  pages={349-57}
}
Both neurogenic influences and the regulatory neuropeptide substance P (SP) have been implicated in the development of joint inflammation. Using the laser Doppler perfusion imaging technique to quantify relative changes in joint blood flow, the effects of nerve stimulation and topical SP application were examined in normal and chronically inflamed rat knee joints. Synovial inflammation was induced by unilateral intra-articular injection of Freund's complete adjuvant and experiments were carried… CONTINUE READING

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