Prolonged administration: A new concept for increasing the spectrum and effectiveness of anthelmintics

@article{Prichard1978ProlongedAA,
  title={Prolonged administration: A new concept for increasing the spectrum and effectiveness of anthelmintics},
  author={Roger Prichard and D. R. Hennessy and J. W. Steel},
  journal={Veterinary Parasitology},
  year={1978},
  volume={4},
  pages={309-315}
}
The pharmacology of anthelmintics in livestock.
  • R. Prichard
  • Biology
    International journal for parasitology
  • 1987
The role of absorbed drug in the efficacy of oxfendazole against gastrointestinal nematodes
TLDR
Findings demonstrate that absorbed drug is important for the efficacy of OFZ against nematodes in the abomasum and small intestine and may be more important than unabsorbed drug passing down the gastrointestinal tract.
The mode of action of some benzimidazole drugs on Trichinella spiralis.
TLDR
Measurements of free glucose, glycogen reserves and soluble protein in the treated larvae indicate that in vivo, mebendazole and thiabendazoles clearly diminish free glucose levels, although in vitro only mebENDazole produces the same diminution.
Resistance to benzimidazole anthelmintics in field strains of Ostertagia and Nematodirus in sheep.
TLDR
A relationship was established between egg counts and adult worm counts 10 days post-treatment, which suggested that for Ostertagia the worm count could be predicted from the geometric mean egg count from about 10 animals, and an anthelmintic efficiency assay using pre- and post- treatment faecal egg counts should provide a satisfactory diagnostic procedure.
Potentiation of the anthelmintic activity of oxfendazole by parbendazole.
TLDR
The demonstration of PBZ-OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis.
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Absorption, metabolism and elimination of thiabendazole in farm animals and a method for its estimation in biological materials.
TLDR
Radioactive thiabendazole administered orally to farm animals (goats, cattle and swine) as single doses of 50 to 200 mg/kg was rapidly absorbed and metabolized, and effectively excreted, and trace quantities of the unchanged compound were present.
Radioimmunoassay of oxfendazole in bovine, equine, or canine plasma or serum.
TLDR
A simple radioimmunoassay was developed so that oxfendazole could be measured directly in a 0.1-ml aliquot of diluted or undiluted plasma and cross-reactivity was determined for closely related compounds and metabolites.