Prolonged activation of mitochondrial conductances during synaptic transmission.

@article{Jonas1999ProlongedAO,
  title={Prolonged activation of mitochondrial conductances during synaptic transmission.},
  author={Elizabeth Ann Jonas and Joann Buchanan and Leonard K Kaczmarek},
  journal={Science},
  year={1999},
  volume={286 5443},
  pages={1347-50}
}
Although ion channels have been detected in mitochondria, scientists have not been able to record ion transport in mitochondria of intact cells. A variation of the patch clamp technique was used to record ion channel activity from intracellular organelles in the presynaptic terminal of the squid. Electron microscopy indicated that mitochondria are numerous in this terminal and are the only organelles compatible with the tips of the pipettes. Before synaptic stimulation, channel activity was… CONTINUE READING

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