Prolonged Weakness and Vecuronium

  title={Prolonged Weakness and Vecuronium},
  author={D. Bernstein},
  journal={Annals of Internal Medicine},
  • D. Bernstein
  • Published 1993
  • Medicine
  • Annals of Internal Medicine
TO THE EDITOR: The recent article by Kupfer and colleagues [1] describes prolonged weakness in 5 of 10 patients who received long-term therapy with vecuronium. In none of these cases, however, was the dose of vecuronium given in mg/kg per day. Four of the ten patients received average doses between 6.7 and 12 mg/hunusually high doses. Metabolites of vecuronium may play a role in prolonged paralysis. The metabolite 3-desacetylvecuronium has neuromuscular blocking activity in feline models [2… Expand
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