Prolonged Versus Intermittent Infusion of β-Lactam Antibiotics: A Systematic Review and Meta-Regression of Bacterial Killing in Preclinical Infection Models

  title={Prolonged Versus Intermittent Infusion of $\beta$-Lactam Antibiotics: A Systematic Review and Meta-Regression of Bacterial Killing in Preclinical Infection Models},
  author={Sofie A.M. Dhaese and Aaron James Heffernan and David Liu and Mohd Hafiz Abdul-Aziz and Veronique Stove and Vincent H. Tam and Jeffrey Lipman and Jason Alexander Roberts and Jan J. De Waele},
  journal={Clinical Pharmacokinetics},
  pages={1237 - 1250}
Administering β-lactam antibiotics via prolonged infusions for critically ill patients is mainly based on preclinical evidence. Preclinical data on this topic have not been systematically reviewed before. The aim of this study was to describe the pharmacokinetic/pharmacodynamic (PK/PD) indices and targets reported in preclinical models and to compare the bactericidal efficacy of intermittent and prolonged infusions of β-lactam antibiotics. The MEDLINE and EMBASE databases were searched. To… Expand

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