Prolonged Systemic Delivery of Peptide Drugs by Long-Circulating Liposomes: Illustration with Vasopressin in the Brattleboro Rat

@article{Woodle1992ProlongedSD,
  title={Prolonged Systemic Delivery of Peptide Drugs by Long-Circulating Liposomes: Illustration with Vasopressin in the Brattleboro Rat},
  author={Martin C. Woodle and Gert Storm and Mary S. Newman and Jill J. Jekot and Lila R. Collins and Francis J. O. Martin and Jr Francis C. Szoka},
  journal={Pharmaceutical Research},
  year={1992},
  volume={9},
  pages={260-265}
}
The value of novel systemically long-circulating liposomes to prolong the duration of an antidiuretic hormone, arg8-vasopressin (VP), was investigated as a representative of low molecular weight pep-tides with rapid clearance. Cholesterol content was found to have a controlling effect on VP release in serum. Three types of liposomes were selected for urine… CONTINUE READING