Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus

@article{Rossing2001ProlongedQI,
  title={Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus},
  author={Peter Rossing and Lars Breum and Atheline Major-Pedersen and Akihiko Sato and H Winding and A Pietersen and Jens Kastrup and H.-H. Parving},
  journal={Diabetic Medicine},
  year={2001},
  volume={18}
}
SUMMARY 

Metabolic and cardiovascular changes in women with polycystic ovary syndrome

  • H. Meden-VrtovecB. VrtovecJ. Osredkar
  • Medicine, Biology
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2007

Acute hyperglycaemia disturbs cardiac repolarization in Type 1 diabetes

TLDR
Investigation of whether acute hyperglycaemia affects the QTc duration and theQTc dispersion in patients with Type 1 diabetes and in healthy volunteers found no significant changes.

G-CSF Has a Therapeutic Effect on Cardıomyopathy in Diabetic Rats

TLDR
The electro-cardiogram of many diabetes patients show several alterations from normal patterns and increase of QT interval duration reflects the abnormalities of ventricular myocardial re polarization, which has been associated with sudden death in diabetes patients.

Cardiac repolarization and depolarization in people with Type 1 diabetes with normal ejection fraction and without known heart disease: a case‐control study

TLDR
To investigate depolarization and repolarization durations in people with Type 1 diabetes, including the relationship to age, researchers used a probabilistic approach to estimate the duration of fasting and fasting periods.

Evaluation of electrocardiographic parameters for early diagnosis of autonomic dysfunction in children and adolescents with type‐1 diabetes mellitus

The aim of this study was to identify the sensitivity of electrocardiogram (ECG) in early diagnosis of cardiac autonomic function disorder in children with type 1 diabetes mellitus.

Incidence and outcomes of long QTc in acute medical admissions

Prolonged QT interval on electrocardiogram (ECG) increases the risk of ventricular arrhythmia. Patients admitted to acute medical units (AMU) may be at risk of QT prolongation from multiple,

Evidence based diabetology : strategies to prevent macrovascular disease and to reduce mortality

TLDR
This thesis was on prevention and therapy of macrovascular disease in patients with type 1 and type 2 DM, as well as on comparisons with patients without DM, and whether the effectiveness of certain treatment forms differs between patients with and without DM.

Asociación de la neuropatía autonómica cardiovascular y el intervalo QT prolongado con la morbimortalidad cardiovascular en pacientes con diabetes mellitus tipo 2

TLDR
It was found that long QTc interval was the only variable significantly associated with cardiovascular morbidity and mortality in the multiple logistic regression analysis.

Association of hypoglycaemia and risk of cardiac arrhythmia in patients with diabetes mellitus: A systematic review and meta‐analysis

TLDR
A systematic review and meta‐analysis found that hypoglycaemia is associated with increased cardiovascular risk among individuals with diabetes mellitus and suggested that autonomic changes leading to increased cardiac arrhythmia risk may be triggered.

Incidence of prolonged QTc and severe hypoglycemia in type 1 diabetes: the EURODIAB Prospective Complications Study

TLDR
Severe hypoglycemia was not associated with incidence QTc prolongation in type 1 diabetic patients from the EURODIAB PCS, independently of age, sex, HbA1c, blood pressure, BMI, physical activity, distal symmetry and autonomic neuropathy.
...

References

SHOWING 1-10 OF 31 REFERENCES

The value of QT interval dispersion for identification of total mortality risk in non‐insulin‐dependent diabetes mellitus

TLDR
The value of QT interval dispersion for identification of total mortality risk in non‐insulin‐dependent diabetes mellitus is studied.

QT and QTc dispersion are accurate predictors of cardiac death in newly diagnosed non-insulin dependent diabetes: cohort study

TLDR
QT dispersion, a new but related electrocardiographic variable, predicts cardiac death in patients who have chronic heart failure, peripheral vascular disease, or essential hypertension, and it was investigated whether it also predicted cardiacDeath in diabetic patients.

Microalbuminuria: an early marker of renal involvement in diabetes.

TLDR
It is the long-term microvascular complications, specifically diabetic nephropathy and associated retinopathy, neuropathy, and large vessel disease, that are the main determinants of disability and increased mortality in diabetics.

The relation between QTc interval prolongation and diabetic complications. The EURODIAB IDDM Complication Study Group

TLDR
Corrected QT in insulin-dependent diabetic female patients is longer than in male patients, even in the absence of diabetic complications known to increase the risk of corrected QT prolongation.

Prevalence of QT Prolongation in a Type 1 Diabetic Population and Its Association with Autonomic Neuropathy

TLDR
The prevalence of QT prolongation in a large random sample of Type 1 diabetic patients in Piemonte, Italy and its association with autonomic neuropathy were assessed and no correlation was found between QT interval and age or disease duration.

Sensitivity and specificity of QTc dispersion for identification of risk of cardiac death in patients with peripheral vascular disease

TLDR
QTc dispersion may be a cheap and non-invasive way of assessing the risk of cardiac death in patients with peripheral vascular disease and should help in deciding whether cardiac investigations and treatments should be undertaken in individual patients as well as helping to plan the most appropriate treatment for their peripheralascular disease.

Predictors of mortality in insulin dependent diabetes: 10 year observational follow up study

TLDR
Abnormally increased urinary albumin excretion and other potentially modifiable risk factors such as hypertension, smoking, poor glycaemic control, and social class predict increased mortality in insulin dependent diabetes.

QT dispersion in essential hypertension.

TLDR
Measurement of QT dispersion might be a simple, non-invasive screening procedure to identify those hypertensives at greatest risk of sudden death.

QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes

TLDR
It is indicated that QTc-max but not QT-disp is an independent predictor of all cause and cardiovascular mortality in NIDDM patients.