Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells

  title={Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1$\alpha$ and HIF-2$\alpha$ Expression in Lung Epithelial Cells},
  author={Tokujiro Uchida and Fabrice Rossignol and Michael A. Matthay and R{\'e}mi Mounier and Sylvianne Couette and Eric Clottes and Christine Cl{\'e}rici},
  journal={Journal of Biological Chemistry},
  pages={14871 - 14878}
Transcriptional adaptations to hypoxia are mediated by hypoxia-inducible factor (HIF)-1, a heterodimer of HIF-α and aryl hydrocarbon receptor nuclear translocator subunits. The HIF-1α and HIF-2α subunits both undergo rapid hypoxia-induced protein stabilization and bind identical target DNA sequences. When coexpressed in similar cell types, discriminating control mechanisms may exist for their regulation, explaining why HIF-1α and HIF-2α do not substitute during embryogenesis. We report that, in… 

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