Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance

@inproceedings{Hoeks2010ProlongedFI,
  title={Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance},
  author={Joris Hoeks and Noud Antonius van Herpen and Marco Mensink and Esther Moonen-Kornips and Denis H A van Beurden and Matthijs K C Hesselink and Patrick Schrauwen},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Type 2 diabetes and insulin resistance have been associated with mitochondrial dysfunction, but it is debated whether this is a primary factor in the pathogenesis of the disease. To test the concept that mitochondrial dysfunction is secondary to the development of insulin resistance, we employed the unique model of prolonged fasting in humans. Prolonged fasting is a physiologic condition in which muscular insulin resistance develops in the presence of increased free fatty acid (FFA… CONTINUE READING
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Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes

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