Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis

@inproceedings{Zhu2010ProlongedAO,
  title={Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis},
  author={Fei Zhu and Pu Wang and Norman H. Lee and Mary B Goldring and Konstantinos Konstantopoulos},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Excessive mechanical loading of articular cartilage producing hydrostatic stress, tensile strain and fluid flow leads to irreversible cartilage erosion and osteoarthritic (OA) disease. Since application of high fluid shear to chondrocytes recapitulates some of the earmarks of OA, we aimed to screen the gene expression profiles of shear-activated chondrocytes and assess potential similarities with OA chondrocytes. METHODOLOGY/PRINCIPAL FINDINGS Using a cDNA microarray technology, we… CONTINUE READING

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