Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes

@inproceedings{Hermosilla2017ProlongedAA,
  title={Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes},
  author={Tamara Hermosilla and Mat{\'i}as Encina and Danna Morales and Cristian Moreno and Carolina Conejeros and Hilda M. Alfaro-Vald{\'e}s and Felipe Lagos-Meza and Felipe Simon and Christophe Altier and Diego Varela},
  booktitle={Scientific Reports},
  year={2017}
}
The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit CaV1.2 with auxiliary subunits CaVα2δ and CaVβ. Its traffic has been shown to be controlled by these subunits and by the activation of various G-protein coupled receptors (GPCR). Here, we explore the consequences of the prolonged activation of angiotensin receptor type 1 (AT1R) over CaV1.2 channel trafficking. Bioluminescence Resonance Energy Transfer (BRET) assay between… CONTINUE READING