Prolongation of islet xenograft survival by in vitro culture of rat megaislets in 95% O2.

@article{Lacy1982ProlongationOI,
  title={Prolongation of islet xenograft survival by in vitro culture of rat megaislets in 95% O2.},
  author={Paul E. Lacy and Edward H. Finke and Christine G. Janney and Joseph M. Davie},
  journal={Transplantation},
  year={1982},
  volume={33 6},
  pages={588-92}
}
Individual rat islets could be aggregated into single megaislets in vitro and the megaislets remained morphologically and functionally intact after a 7-day period of culture in the presence of 95% O2 and 5% CO2. Cultured rat megaislets transplanted beneath the renal capsule of diabetic mice produced normoglycemia in the recipients and the survival of the xenografts was markedly prolonged by the 7-day exposure of a high oxygen tension. A single injection of antilymphocyte sera to mouse and rat… CONTINUE READING

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