Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates

  title={Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates},
  author={Roger A Nicoll and John Eccles and Takeo Oshima and Francisco J. Rubia},
IT is well documented that barbiturates dramatically prolong presynaptic inhibition1–4. Their effect on postsynaptic inhibition is less clear, although the available evidence suggests that a similar enhancement may occur at some sites5–7. Since the inhibitory postsynaptic potentials (i.p.s.p.s) in hippocampal neurones are unusually large and the neurones are readily penetrable by microelectrodes8, we have studied the effect of barbiturates on these i.p.s.p.s in detail. We have found that… CONTINUE READING

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