Prolongation of heart allograft survival after long-term expression of soluble MHC class I antigens and vIL-10 in the liver by AAV-plasmid-mediated gene transfer

@article{Doenecke2008ProlongationOH,
  title={Prolongation of heart allograft survival after long-term expression of soluble MHC class I antigens and vIL-10 in the liver by AAV-plasmid-mediated gene transfer},
  author={Axel Doenecke and Eibe Frank and Marcus Nils Scherer and H J Schlitt and Edward Kenneth Geissler},
  journal={Langenbeck's Archives of Surgery},
  year={2008},
  volume={393},
  pages={343-348}
}
The essential prerequisite for successful gene therapy in vivo is an effective and long-lasting transfer of the desired gene into the respective cell type or tissue. Over the last decades, many different methods have been developed for this purpose. The use of plasmid DNA seems to be a good alternative to the commonly used viral vectors because its large-scale production is simple, and side effects are low. Unfortunately, most reports describe only short-term expression in vivo, probably due to… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

progress and prospects : hydrodynamic gene delivery

  • BL Hodges, KM Taylor, MF Joseph, SA Bourgeois, RK Scheule
  • Gene therapy
  • 2007

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