Prolongation of corneal allograft survival by an interleukin-2-immunoglobulin fusion protein in mice

@article{Zhang1998ProlongationOC,
  title={Prolongation of corneal allograft survival by an interleukin-2-immunoglobulin fusion protein in mice},
  author={Er-ping Zhang and Thomas Pohl and Silvia Bulfone-Paus and Joachim Wachtlin and Ulrich Kunzendorf and Friedrich Hoffmann},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={1998},
  volume={236},
  pages={486-492}
}
· Background: Interleukin 2 (IL2) production by activated T-helper cells leads to activation and proliferation of cytotoxic T cells. Recently, an IL2-IgG fusion protein was found to suppress cell-mediated and humoral immune responses in mice. · Methods: We used the genetically engineered murine IL2-IgG2b fusion protein in a fully MHC-mismatched mouse… CONTINUE READING