Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?

@article{Vigneault2011ProlongationOC,
  title={Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?},
  author={Patrick Vigneault and Nisrin Ali Kaddar and Sarah Bourgault and Bertrand Caillier and Sylvie Pilote and Dany Patoine and Clermont Simard and Benoit Drolet},
  journal={Journal of cardiovascular pharmacology},
  year={2011},
  volume={57 6},
  pages={
          690-5
        }
}
INTRODUCTION Paliperidone (9-hydroxyrisperidone) is a second-generation antipsychotic. As observed with risperidone, QT interval prolongation was reported with paliperidone. OBJECTIVE The aim was to evaluate the effects of paliperidone on cardiac ventricular repolarization. METHODS (1) Patch-clamp experiments: Human ether-a-go-go-related gene (HERG)- or KCNQ1 + KCNE1-transfected cells were exposed to 0.1-100 μmol/L paliperidone (N = 39 cells, total) to assess the drug effect on HERG and… CONTINUE READING
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