Proline residues in the maturation and degradation of peptide hormones and neuropeptides.

@article{Mentlein1988ProlineRI,
  title={Proline residues in the maturation and degradation of peptide hormones and neuropeptides.},
  author={Rolf Mentlein},
  journal={FEBS letters},
  year={1988},
  volume={234 2},
  pages={251-6}
}
The proteases involved in the maturation of regulatory peptides like those of broader specificity normally fail to cleave peptide bonds linked to the cyclic amino acid proline. This generates several mature peptides with N-terminal X-Pro-sequences. However, in certain non-mammalian tissues repetitive pre-sequences of this type are removed by specialized dipeptidyl (amino)peptidases during maturation. In mammals, proline-specific proteases are not involved in the biosynthesis of regulatory… CONTINUE READING

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