Proline motifs in peptides and their biological processing

@article{Vanhoof1995ProlineMI,
  title={Proline motifs in peptides and their biological processing},
  author={Greet Vanhoof and Filip Goossens and Ingrid De Meester and Dirk Hendriks and Simon Lodewijk Scharpe},
  journal={The FASEB Journal},
  year={1995},
  volume={9},
  pages={736 - 744}
}
Many biologically important peptide sequences contain proline. It confers unique conformational constraints on the peptide chain in that the side‐chain is cyclized back onto the backbone amide position. Inside an a‐helix the possibility of making hydrogen bonds to the preceding turn is lost and a kink will be introduced. The conformational restrictions imposed by proline motifs in a peptide chain appear to imply important structural or biological functions as can be deduced from their often… 

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