Proline-induced potentiation of glutamate transmission

  title={Proline-induced potentiation of glutamate transmission},
  author={Susan M Cohen and J. Victor Nadler},
  journal={Brain Research},
The amino acid proline has long been suspected to serve as a modulator of synaptic transmission in the mammalian brain, but no such function has been identified. The selective expression of high affinity proline transport by a subset of glutamate pathways suggested that proline might play a role in synaptic transmission at these sites. This idea was tested with use of one such pathway, the Schaffer collateral-commissural projection to CA1 pyramidal cells of the rat hippocampus. Proline enhanced… CONTINUE READING


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