Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition.

Abstract

A series of novel proline-based reduced dipeptides was developed and evaluated for a direct Michael addition of ketones and aldehydes to nitroalkenes. Excellent yields (up to 95%), diastereoselectivities (up to 98% dr) and enantioselectivities (up to 98% ee) were achieved in the presence of 5 mol% catalyst without any additional additives at room temperature.

DOI: 10.1039/c1ob05679d

Cite this paper

@article{Cao2011ProlinebasedRD, title={Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition.}, author={Xiaohui Cao and Ge Wang and Richeng Zhang and Yingying Wei and Wei Wang and Huichao Sun and Ligong Chen}, journal={Organic & biomolecular chemistry}, year={2011}, volume={9 19}, pages={6487-90} }