Proline and proline derivatives as anticonvulsants.

@article{Sarhan1989ProlineAP,
  title={Proline and proline derivatives as anticonvulsants.},
  author={Shakir Sarhan and Nikolaus Seiler},
  journal={General pharmacology},
  year={1989},
  volume={20 1},
  pages={
          53-60
        }
}
The N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline-Enriched Methanol Fraction from Sideroxylon obtusifolium Shows an Anticonvulsant Activity Associated with its Anti-inflammatory/Antioxidant Actions
TLDR
Significant anticonvulsant effects for N-methyl-(2S,4R)-trans-4-hydroxy-L-proline are shown, probably related to its anti-inflammatory/antioxidant properties.
Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats?
TLDR
Specific suppression or at least restriction of the tonic phase was observed in all groups of immature rats, the effect was more marked 24 hours after vigabatrin than at shorter intervals, which varies markedly during development.
A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice
TLDR
NMP is highlighted as a promising candidate for the protection of the hippocampus, as shown by the icv Pilo model, which induced cognitive deficits, cell damage, increased GFAP, Iba-1, and GAT1 expression in the hippocampus.
Enantioselective Recognition of Proline Enantiomers Using Sulfhydryl-modified Self-assembled Gold Electrodes
ABSTRACT Penicillamine, cysteine, and N-isobutyryl-cysteine enantiomers self-assembled gold electrodes were used for the enantioselective recognition of proline in the presence of copper(II). High
Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control.
TLDR
Current evidence supports a trial of this agent as adjunctive therapy in patients with refractory seizure disorders, and future investigation of vigabatrin monotherapy and its efficacy relative to established agents is awaited with interest.
Vigabatrin: A Novel Therapy for Seizure Disorders
TLDR
Vigabatrin improves seizure control as add-on therapy for refractory partial seizures and may produce therapeutic benefits in the treatment of infantile spasms and is generally well tolerated.
...
...

References

SHOWING 1-10 OF 41 REFERENCES
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine
TLDR
This observation is the first example of the synergistic interaction of two inhibitory neuronal systems resulting in the amplification of the anticonvulsant effect of GABA-T in animal seizure models.
L-proline as a glutamate antagonist at a crustacean neuromuscular junction.
The fast as well as the slow contractions of the adductor muscle in the claw of Procambarus clarkii are inhibited by L-proline. This inhibition is dose dependent and decreases with increasing
Glycine potentiates the action of some anticonvulsant drugs in some seizure models
TLDR
The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures, suggesting that this mechanism is not effective in all seizure models.
Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists.
TLDR
DL-2-amino-5-phosphonovalerate was the most effective in delaying or preventing seizures and L-Glutamic acid diethylester was also effective but at significantly higher doses, which were also associated with marked sedation.
...
...