Proliferative potential after DNA damage and non-homologous end joining are affected by loss of securin

  title={Proliferative potential after DNA damage and non-homologous end joining are affected by loss of securin},
  author={Juan Antonio Bernal and Magali Roche and Cristina M{\'e}ndez-Vidal and Agueda G Espina and Mar{\'i}a Tortolero and J. A. Pintor-Toro},
  journal={Cell Death and Differentiation},
The faithful repair of DNA damage, especially chromosomal double-strand breaks (DSBs), is crucial for genomic integrity. We have previously shown that securin interacts with the Ku70/80 heterodimer of the DSB non-homologous DNA end-joining (NHEJ) repair machinery. Here we demonstrate that securin deficiency compromises cell survival and proliferation, but only after genotoxic stress. Securin−/− cells show a significant increase in gross chromosomal rearrangements and chromatid breaks after DNA… CONTINUE READING


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