Proliferative injection therapy for osteoarthritis: a systematic review

  title={Proliferative injection therapy for osteoarthritis: a systematic review},
  author={Miso Krsticevic and Milka Jeri{\'c} and Svjetlana Dosenovic and Antonia Jeli{\vc}i{\'c} Kadi{\'c} and Livia Puljak},
  journal={International Orthopaedics},
PurposeTo systematically analyse randomised controlled trials (RCTs) about efficacy and safety of proliferative injection therapy (prolotherapy) for treatment of osteoarthritis (OA).MethodsCENTRAL, Embase and MEDLINE were searched. Two reviewers independently conducted screening and data extraction. RCTs were assessed with the Cochrane risk of bias tool. Type of treatment, study design, dosing, efficacy outcomes and safety outcomes were analysed. The protocol was registered in PROSPERO… 
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1. Krstičević M, Jerić M, Došenović S, Jeličić Kadić A, Puljak L. Proliferative injection therapy for osteoarthritis: A systematic review. Int Orthop 2017;41:671-9. 2. Bae G, Kim S, Lee S, Lee WY,
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Intra-articular prolotherapy provided significant relief of sacroiliac joint pain, and its effects lasted longer than those of steroid injections, and to confirm the safety of the procedure and to validate an appropriate injection protocol.
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