Proliferative injection therapy for osteoarthritis: a systematic review

@article{Krsticevic2017ProliferativeIT,
  title={Proliferative injection therapy for osteoarthritis: a systematic review},
  author={Miso Krsticevic and Milka Jeri{\'c} and Svjetlana Dosenovic and Antonia Jeli{\vc}i{\'c} Kadi{\'c} and Livia Puljak},
  journal={International Orthopaedics},
  year={2017},
  volume={41},
  pages={671-679}
}
PurposeTo systematically analyse randomised controlled trials (RCTs) about efficacy and safety of proliferative injection therapy (prolotherapy) for treatment of osteoarthritis (OA).MethodsCENTRAL, Embase and MEDLINE were searched. Two reviewers independently conducted screening and data extraction. RCTs were assessed with the Cochrane risk of bias tool. Type of treatment, study design, dosing, efficacy outcomes and safety outcomes were analysed. The protocol was registered in PROSPERO… 
The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: A Randomized Controlled Study.
TLDR
Findings suggest that dextrose prolotherapy is effective at reducing pain and improving the functional status and quality of life of patients with KOA.
The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis
TLDR
Results of the present study suggested a significant decrease in the overall WOMAC score of patients who undergo either PRP therapy or PRL, which led to an improvement in the quality of life of patients with knee OA shortly after the first injection.
Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies
TLDR
Platelet-rich plasma is beginning to replace the more common injectable therapies of intra-articular corticosteroids and hyaluronic acid, but larger trials are needed to confirm this effect.
Prolotherapy as an intervention for chronic, refractory musculoskeletal pain
  • A. Nair
  • Medicine
    Saudi journal of anaesthesia
  • 2021
TLDR
Ibuprofen and NSAID use in COVID-19 infected patients is not associated with worse outcomes and non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection.
THE EFFECTS OF INJECTING INTRA ARTICULAR PLATELET-RICH PLASMA ON PAIN SCORES IN KNEE JOINT OSTEOARTHRITIS
TLDR
Platelet rich plasma is safe, cost effective and minimally invasive in reducing pain scores and functional limitation in knee osteoarthritis.
Prevention of post-traumatic osteoarthritis after intra-articular knee fractures using hyaluronic acid: a randomized prospective pilot study
TLDR
Preliminary results support a direct role for hyaluronic acid in the acute phase of the inflammatory process that follows articular injury and provides initial evidence for the efficacy of IA HA.
The balancing act of hospital medical oxygen demand and supply: The need of the hour in the COVID-19 pandemic
1. Krstičević M, Jerić M, Došenović S, Jeličić Kadić A, Puljak L. Proliferative injection therapy for osteoarthritis: A systematic review. Int Orthop 2017;41:671-9. 2. Bae G, Kim S, Lee S, Lee WY,
A taxonomy of risk-associated alternative health practices: A Delphi study.
TLDR
An initial taxonomy of risk‐associated alternative health care practices was identified and categorized into general practices that conflict with biomedical care or largely untested therapies, alternative beliefs systems, physical manipulative alternative therapies, and herbal and nutritional supplements.
...
...

References

SHOWING 1-10 OF 48 REFERENCES
A Systematic Review of Prolotherapy for Chronic Musculoskeletal Pain
TLDR
There are limited high-quality data supporting the use of prolotherapy in the treatment of musculoskeletal pain or sport-related soft tissue injuries, and positive results compared with controls have been reported in nonrandomized and randomized controlled trials.
Treatment of primary and secondary osteoarthritis of the knee.
TLDR
The three interventions reviewed in this report are widely used in the treatment of OA of the knee, yet the best available evidence does not clearly demonstrate clinical benefit.
Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis: A systematic review and meta-analysis
TLDR
Overall, prolotherapy conferred a positive and significant beneficial effect in the treatment of knee OA, and adequate powered, longer-term trials with uniform end points are needed to better elucidate the efficacy of prolotherapy.
Dextrose Prolotherapy for Knee Osteoarthritis: A Randomized Controlled Trial
TLDR
Prolotherapy resulted in clinically meaningful sustained improvement of pain, function, and stiffness scores for knee osteoarthritis compared with blinded saline injections and at-home exercises and use of prescribed postprocedure opioid medication.
Effect of regenerative injection therapy on function and pain in patients with knee osteoarthritis: a randomized crossover study.
TLDR
The use of RIT is associated with a marked reduction in symptoms, which was sustained for over 24 weeks, and WOMAC scores improved in both groups by 47.3% and 36.2%.
Dextrose and morrhuate sodium injections (prolotherapy) for knee osteoarthritis: a prospective open-label trial.
TLDR
Prolotherapy using dextrose and morrhuate sodium injections for participants with mild-to-severe KOA resulted in safe, significant, sustained improvement of WOMAC-based knee pain, function, and stiffness scores compared to baseline status.
Prolotherapy injections for chronic low-back pain.
TLDR
There is conflicting evidence regarding the efficacy of prolotherapy injections in reducing pain and disability in patients with chronic low-back pain, and in the presence of co-interventions, Prolotherapy injections were more effective than control injections, more so when both injections and co- interventions were controlled concurrently.
A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain.
TLDR
Intra-articular prolotherapy provided significant relief of sacroiliac joint pain, and its effects lasted longer than those of steroid injections, and to confirm the safety of the procedure and to validate an appropriate injection protocol.
Prolotherapy: A Clinical Review of Its Role in Treating Chronic Musculoskeletal Pain
  • L. Distel, T. Best
  • Medicine, Psychology
    PM & R : the journal of injury, function, and rehabilitation
  • 2011
...
...