Proliferative effect of Apidra® (insulin glulisine), a rapid-acting insulin analogue on mammary epithelial cells

  title={Proliferative effect of Apidra® (insulin glulisine), a rapid-acting insulin analogue on mammary epithelial cells},
  author={A. Shukla and H. Enzmann and D. Mayer},
  journal={Archives Of Physiology And Biochemistry},
  pages={119 - 126}
  • A. Shukla, H. Enzmann, D. Mayer
  • Published 2009
  • Biology, Medicine
  • Archives Of Physiology And Biochemistry
  • The structural modification of insulin results in the generation of insulin analogues that show altered binding affinities to the insulin receptor and/or the IGF-I receptor, and as a consequence insulin analogues may have altered mitogenic potency. We analysed the proliferative effect of the rapid-acting insulin analogue Apidra® (insulin glulisine) on mammary epithelial cells. We show that Apidra and Actrapid® (recombinant human insulin) have similar proliferative effects on benign MCF10A and… CONTINUE READING
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