Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium.

@article{Tucker2010ProliferativeAT,
  title={Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium.},
  author={Eric S. Tucker and Maria K Lehtinen and Tom Maynard and Mariela Zirlinger and C. Capdevielle Dulac and Nancy E. Rawson and Larysa Halyna Pevny and Anthony-Samuel LaMantia},
  journal={Development},
  year={2010},
  volume={137 15},
  pages={2471-81}
}
Neural precursors in the developing olfactory epithelium (OE) give rise to three major neuronal classes - olfactory receptor (ORNs), vomeronasal (VRNs) and gonadotropin releasing hormone (GnRH) neurons. Nevertheless, the molecular and proliferative identities of these precursors are largely unknown. We characterized two precursor classes in the olfactory epithelium (OE) shortly after it becomes a distinct tissue at midgestation in the mouse: slowly dividing self-renewing precursors that express… CONTINUE READING