Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization.

  title={Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization.},
  author={J. Geoffrey Pickering and Lawrence Weir and J Jekanowski and Marianne Kearney and Jeffrey M. Isner},
  journal={The Journal of clinical investigation},
  volume={91 4},
We evaluated the proliferative activity of human atherosclerotic lesions associated with active symptoms of ischemia, by assessing the expression of the proliferating cell nuclear antigen (PCNA). We confirmed in vitro that PCNA, an essential component of the DNA synthesis machinery, is selectively expressed in proliferating human vascular smooth muscle cells. 37 atherosclerotic lesions (18 primary and 19 restenotic) retrieved by directional atherectomy from either coronary or peripheral… Expand
Comparison of proliferative activity in coronary plaques from patients with coronary ischemia. Histopathological and immunohistochemical analysis.
The findings suggest that the excessive proliferation of vascular wall cells, especially SMCs, is involved in the pathogenesis of ACS and in the process of wound repair after angioplasty in humans. Expand
Proliferative activity in coronary atherectomy tissue. Clinical, histopathologic, and immunohistochemical correlates.
Cellular replication, as measured by expression of the PCNA, occurs in a heterogeneous pattern in both primary and restenotic atherosclerotic tissue obtained via directional coronary atherectomy, with no clinicopathologic correlations with respect to clinical outcome. Expand
Histopathology of in-stent restenosis in patients with peripheral artery disease.
Findings support the notion that in-stent restenosis results from SMC hyperplasia and suggest that adjunctive therapies designed to inhibit SMC proliferation may further enhance the utility of endovascular stents. Expand
Proliferation in primary and restenotic coronary atherectomy tissue. Implications for antiproliferative therapy.
The response to injury in existing animal models of angioplasty may follow a very different course of events from the clinical reality in human atherosclerotic coronary arteries and may help explain why current approaches to restenosis therapy have been ineffective. Expand
Apoptosis in human atherosclerosis and restenosis.
The findings of the present study suggest that apoptosis may modulate the cellularity of lesions that produce human vascular obstruction, particularly those with evidence of more extensive proliferative activity. Expand
Biology of the smooth muscle cells in human atherosclerosis
The observation in some cases of chromosome 7 alterations, markers of tumorigenesis, suggests the possible transformation of an advanced atherosclerotic plaque into a neoplastic‐like process. Expand
Topographic analysis of proliferative activity in carotid endarterectomy specimens by immunocytochemical detection of the cell cycle-related antigen Ki-67.
BACKGROUND On the basis of contradictory results found in animal experiments and coronary atherectomy tissue, there is an ongoing debate about the significance of cellular proliferation in humanExpand
Characterization of primary and restenotic atherosclerotic plaque from the superficial femoral artery: Potential role of Smad3 in regulation of SMC proliferation.
Differences in cellular composition and cell proliferation in conjunction with the finding that Smad3 is expressed exclusively in restenotic disease suggest that TGF-beta, through Smad 3 signaling, may play an essential role in SMC proliferation and the pathophysiology of restenosis in humans. Expand
Intimal Cell Density in Postangioplasty Versus Primary Coronary and Peripheral Lesions: A Systematic Study on Human Atherectomy Samples
Examination of intimal cell numbers and cell types in tissue of 23 postangioplasty lesions biopsied by directional atherectomy suggested primary lesion hypercellularity is suggested to be related to the formation and progression of native arteriosclerosis. Expand
Cellular proliferation in complicated versus uncomplicated atherosclerotic lesions: total cell population, foam cells and newly formed microvessels.
Overall proliferative activity was found significantly higher among complicated type VI lesions compared to uncomplicated type V lesions, and it seems that, although total cell population and foam cells are probably affected by the stimulating factors that are expressed during acute events, the same does not apply to the endothelial cells lining plaque vessels. Expand