Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.

@article{Frungieri2002ProliferativeAO,
  title={Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.},
  author={M B Frungieri and Stephan Weidinger and Viktor Meineke and Frank Michael K{\"o}hn and Artur Mayerhofer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 23},
  pages={
          15072-7
        }
}
Mast-cell products can stimulate fibroblast proliferation, implying that these cells are key players in fibrosis. One mast-cell product, the serine protease tryptase, is known to activate protease-activated receptor 2 (PAR2) and cause proliferation of fibroblasts. We found that recombinant tryptase, human mast-cell (HMC-1) supernatant, which contains tryptase, and the PAR2-activating peptide SLIGKV exert fibroproliferative actions in human fibroblasts. Here we report insights into this action… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 98 CITATIONS, ESTIMATED 47% COVERAGE

Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes.

  • Clinical and experimental rheumatology
  • 2007
VIEW 12 EXCERPTS
CITES RESULTS
HIGHLY INFLUENCED

Proteases in Human Diseases

VIEW 8 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2003
2019

CITATION STATISTICS

  • 16 Highly Influenced Citations

Similar Papers

Loading similar papers…