Proliferative Typhlocolitis With Multinucleated Giant Cells: A Nonspecific Enteropathy in Immunodeficient Sentinel Mice.

@article{Casey2018ProliferativeTW,
  title={Proliferative Typhlocolitis With Multinucleated Giant Cells: A Nonspecific Enteropathy in Immunodeficient Sentinel Mice.},
  author={Kerriann M Casey and A L Johnson and Melea N Hunrath and Jenelle K Fraser and Nicole C McCowan and Katherine Wasson and Rosalinda A. Doty and Stephen M. Griffey and Denise M Imai},
  journal={Veterinary pathology},
  year={2018},
  pages={
          300985818798106
        }
}
Beginning in 2015, athymic nude sentinel mice from conventional, medium-, and high-security facilities presented to the Comparative Pathology Laboratory (CPL) with weight loss, diarrhea, and/or rectal prolapse. Regardless of whether clinical signs were present or absent, the gross observation of ceco-colonic thickening corresponded histologically to pleocellular typhlocolitis with mucosal hyperplasia and lamina proprial multinucleated cells. A subset of affected sentinels exhibited… CONTINUE READING
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