Proliferation of prostate cancer cells and activity of neutral endopeptidase is regulated by bombesin and IL-1beta with IL-1beta acting as a modulator of cellular differentiation.

@article{Albrecht2004ProliferationOP,
  title={Proliferation of prostate cancer cells and activity of neutral endopeptidase is regulated by bombesin and IL-1beta with IL-1beta acting as a modulator of cellular differentiation.},
  author={Martin Albrecht and Jolanta Doroszewicz and Sonja Gillen and Iara Gomes and Beate Wilhelm and Thomas Stief and Gerhard Aum{\"u}ller},
  journal={The Prostate},
  year={2004},
  volume={58 1},
  pages={82-94}
}
BACKGROUND Neutral endopeptidase (NEP) is a cell-surface bound enzyme that cleaves and inactivates neuropeptides such as bombesin and substance P and is involved in the transition from hormonally regulated androgen-dependent prostate cancer (PC) to androgen-independent PC. Neuropeptides are implicated in growth regulation of different cell types and function as transmitters between the neuroendocrine and the immune system. METHODS NEP-expression, enzymatic activity of the membrane bound… CONTINUE READING

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