Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient.

@article{Maebashi2003ProliferationOI,
  title={Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient.},
  author={Kazunori Maebashi and Michinari Kudoh and Yayoi Nishiyama and K. Makimura and Yasuki Kamai and Katsuhisa Uchida and Hideyo Yamaguchi},
  journal={Microbiology and immunology},
  year={2003},
  volume={47 2},
  pages={117-24}
}
Three Candida albicans isolates, TIMM 3164, 3165 and 3166 with reduced fluconazole susceptibility, were isolated from two Japanese AIDS patients. We earlier reported that a reduced intracellular accumulation of fluconazole in these isolates played an important role in the resistance mechanism of fluconazole, but we did not exclude the involvement of other factors. We here examined characteristics related to cytochrome P-450 (CYP), especially sterol 14alpha-demethylase encoded by the ERG11 gene… CONTINUE READING