Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.

@article{Hui2008ProliferationOH,
  title={Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.},
  author={Lijian Hui and Kurt Zatloukal and Harald Scheuch and Ewa Stepniak and Erwin F Wagner},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 12},
  pages={3943-53}
}
JNK proteins have been shown to be involved in liver carcinogenesis in mice, but the extent of their involvement in the development of human liver cancers is unknown. Here, we show that activation of JNK1 but not JNK2 was increased in human primary hepatocellular carcinomas (HCCs). Further, JNK1 was required for human HCC cell proliferation in vitro and tumorigenesis after xenotransplantation. Importantly, mice lacking JNK1 displayed decreased tumor cell proliferation in a mouse model of liver… CONTINUE READING

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