Proliferation of glial cells in vivo induced in the neural lobe of the rat pituitary by lithium.

@article{Levine2000ProliferationOG,
  title={Proliferation of glial cells in vivo induced in the neural lobe of the rat pituitary by lithium.},
  author={Seymour Levine and Arthur Saltzman and Arnold William Klein},
  journal={Cell proliferation},
  year={2000},
  volume={33 4},
  pages={203-7}
}
Lithium salts are widely used for treatment of psychiatric illness. Lithium also affects cell proliferation. During investigation of the effect of lithium chloride on the central nervous system (CNS) of nephrectomized rats, we noted numerous mitotic figures in the neural lobe of the pituitary. Morphologic criteria established that the mitotic cells were astrocytes, the supporting glial cells of the CNS, also known as pituicytes. Equimolar doses of chlorides of chemically related cations (sodium… CONTINUE READING

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