Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.

@article{Bretscher2016ProliferationOD,
  title={Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.},
  author={Heidi S Bretscher and Donald T Fox},
  journal={Developmental cell},
  year={2016},
  volume={37 5},
  pages={444-57}
}
Conserved DNA-damage responses (DDRs) sense genome damage and prevent mitosis of broken chromosomes. How cells lacking DDRs cope with broken chromosomes during mitosis is poorly understood. DDRs are frequently inactivated in cells with extra genomes (polyploidy), suggesting that study of polyploidy can reveal how cells with impaired DDRs/genome damage continue dividing. Here, we show that continued division and normal organ development occurs in polyploid, DDR-impaired Drosophila papillar cells… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 9 times. VIEW TWEETS

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…