Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer

  title={Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer},
  author={Kati A Talvinen and Johannes Tuikkala and Olli S. Nevalainen and Anja Rantanen and Pirkko Hirsim{\"a}ki and Jari Sundstr{\"o}m and Pauliina Kronqvist},
  journal={British Journal of Cancer},
  pages={335 - 340}
We introduce a new proliferation marker, securin (pituitary tumour-transforming 1 (PTTG1)), analysed in invasive ductal breast carcinomas by cDNA microarrays and immunohistochemistry. In cDNA microarray of a total of 4000 probes of genes, securin was revealed with a significant change in expression among the several proliferation-related genes studied. The value of securin as a proliferation marker was verified immunohistochemically (n=44) in invasive ductal breast cancer. In follow-up analyses… CONTINUE READING
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