Proliferation marker Ki-S5 as a diagnostic tool in melanocytic lesions.

  title={Proliferation marker Ki-S5 as a diagnostic tool in melanocytic lesions.},
  author={Pierre Rudolph and Christoph Schubert and Barbara Schubert and Reza M. Parwaresch},
  journal={Journal of the American Academy of Dermatology},
  volume={37 2 Pt 1},
BACKGROUND A discrimination between benign and malignant melanocytic lesions is not always possible by conventional histology. OBJECTIVE Our purpose was to determine the proliferative activity in various types of melanocytic neoplasms and to appraise its value as a diagnostic adjunct. METHODS The growth fraction was assessed immunohistochemically in 398 melanocytic lesions by means of the monoclonal antibody Ki-S5 directed to the Ki-67 antigen. In this way, a cut-off level was defined and… CONTINUE READING
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