Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC

  title={Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC},
  author={William Leland Elliott and George Weber},
  journal={Cancer research},
  volume={44 6},
The behavior of phosphoribosylformylglycinamidine ( FGAM ) synthetase (EC activity was elucidated in normal and proliferating tissues and in murine and human neoplasms. Enzymic activity was measured in the 100,000 X g crude supernatant fluid prepared from tissue homogenates. The assay was based on coupling FGAM produced to diazotizable aminoimidazole ribonucleotide. In the crude extracts of normal rat liver and hepatoma 3924A, the apparent KmS of FGAM synthetase for formylglycinamide… CONTINUE READING
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