Proliferation is necessary for both repair and mutation in transgenic mouse cells.

@article{Bielas2000ProliferationIN,
  title={Proliferation is necessary for both repair and mutation in transgenic mouse cells.},
  author={Jason H. Bielas and John A. Heddle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 21},
  pages={11391-6}
}
Proliferating cells are often presumed to be more mutable than quiescent cells because they have less time to repair DNA damage before DNA replication. Direct tests of this hypothesis have been confounded by the need for cell division before a mutation can be detected. We have avoided this problem by showing that the Big Blue mouse cell line permits the dynamic quantification of both lesions and mutations in the complete absence of cell division. These cells carry the bacterial lacI gene in a… CONTINUE READING

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