Proliferation enhancement by spontaneous multiplication of chromosome 7 in rheumatic synovial cells in vitro

Abstract

Mosaic trisomy of chromosome 7 is known to occur in a variety of non-neoplastic hyperproliferative disorders. In long-term cell cultures established from rheumatic synovium with mosaic trisomy 7, we observed a continuous increase in the proportion of cells with trisomy 7 to over 50% by the 10th in vitro passage. Simultaneous in situ hybridization with a… (More)
DOI: 10.1007/BF00210293

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